SCHEMBL5511083

SCHEMBL5511083

CNc1cc(F)cc(F)c1NC

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.42
DHODH Q02127 1/20 0.34
PARP1 P09874 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2541480 0.85 RAPGEF4 (0.48) RAPGEF4DHODHMAPTKMT2A
SCHEMBL22550906 0.80 RAPGEF4 (0.35) RAPGEF4DHODHPARP1
SCHEMBL26093607 0.78 SMN1; SMN2 (0.38) RAPGEF4MAPTKMT2A
SCHEMBL1638888 0.78 CES2 (0.38) RAPGEF4PARP1
SCHEMBL14290382 0.76 RAPGEF4 (0.57) RAPGEF4DHODHMAPTKMT2A
SCHEMBL23252479 0.74 RAPGEF4 (0.41) RAPGEF4DHODHMAPTKMT2A
SCHEMBL12909533 0.74 ERN1 (0.42) RAPGEF4PARP1MAPT
SCHEMBL24072557 0.74 RAPGEF4 (0.41) RAPGEF4DHODHMAPTKMT2A
SCHEMBL107465 0.74 ALDH1A1 (0.34) RAPGEF4PARP1
SCHEMBL4200258 0.74 RAPGEF4 (0.41) RAPGEF4DHODHMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208559-B2 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2007-04-24 US disclosed
US-20060135712-A1 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2006-06-22 US disclosed