Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763870 | 0.99 | SLC6A9 (0.53) | SLC6A9KCNH2CARM1PRMT6CHRM4 | |
| SCHEMBL3765787 | 0.95 | SLC6A9 (0.51) | SLC6A9KCNH2CARM1PRMT6CHRM4 | |
| SCHEMBL708522 | 0.85 | CARM1 (0.50) | SLC6A9KCNH2CARM1PRMT6CHRM4 | |
| SCHEMBL5505967 | 0.84 | ATM (0.47) | SLC6A9KCNH2CARM1PRMT6GLS | |
| SCHEMBL5507361 | 0.84 | CARM1 (0.45) | SLC6A9KCNH2CARM1PRMT6GLS | |
| SCHEMBL5506745 | 0.84 | CARM1 (0.52) | SLC6A9KCNH2CARM1PRMT6CTSD | |
| Hydrochloric Acid SCHEMBL710200 | 0.83 | CARM1 (0.51) | SLC6A9KCNH2CARM1PRMT6CTSD | |
| SCHEMBL5513143 | 0.83 | OPRM1 (0.45) | KCNH2CARM1PRMT6KDM4EALDH1A1 | |
| SCHEMBL712568 | 0.82 | BACE1 (0.48) | SLC6A9KCNH2CARM1PRMT6CHRM4 | |
| SCHEMBL5506743 | 0.82 | CARM1 (0.45) | SLC6A9KCNH2CARM1PRMT6GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |