Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708522 | 0.85 | CARM1 (0.50) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL5510494 | 0.84 | CARM1 (0.44) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL5513876 | 0.83 | GRIN1 (0.43) | CARM1PRMT6KCNH2CTSDBACE1 | |
| SCHEMBL5509542 | 0.83 | CARM1 (0.43) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL712568 | 0.82 | BACE1 (0.48) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL5511375 | 0.82 | GLS (0.44) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL5506362 | 0.81 | CARM1 (0.44) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL5508994 | 0.81 | CARM1 (0.46) | CARM1PRMT6SLC6A9KCNH2 | |
| SCHEMBL5518370 | 0.81 | CARM1 (0.42) | CARM1PRMT6SLC6A9KCNH2CTSD | |
| SCHEMBL15966990 | 0.81 | ALDH1A1 (0.47) | SLC6A9ALDH1A1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |