Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967068 | 0.86 | PDE10A (0.41) | CARM1PRMT6OPRM1PDE10ACTSD | |
| SCHEMBL5505039 | 0.84 | DRD2 (0.43) | DRD4CARM1PRMT6OPRM1DRD3 | |
| SCHEMBL5511564 | 0.83 | CARM1 (0.42) | DRD4CARM1PRMT6CTSDBACE1 | |
| SCHEMBL708522 | 0.83 | CARM1 (0.50) | DRD4CARM1PRMT6OPRM1CTSD | |
| SCHEMBL15967094 | 0.82 | SLC40A1 (0.43) | DRD4PDE10ACACNA1GCACNA1BKCNH2 | |
| SCHEMBL5511022 | 0.81 | CARM1 (0.40) | DRD4CARM1PRMT6CYP2D6CTSD | |
| SCHEMBL5506387 | 0.81 | HDAC3 (0.46) | DRD4CARM1PRMT6OPRM1CTSD | |
| SCHEMBL5518183 | 0.80 | KMT2A (0.47) | DRD4CARM1PRMT6OPRM1HTT | |
| SCHEMBL712568 | 0.80 | BACE1 (0.48) | DRD4CARM1PRMT6DRD3CTSD | |
| SCHEMBL5510494 | 0.80 | CARM1 (0.44) | DRD4CARM1PRMT6OPRM1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |