Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836133 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL10178419 | 0.79 | HRH3 (0.62) | HRH3ALDH1A1KDM4EHRH4 | |
| SCHEMBL6227511 | 0.79 | HRH3 (0.57) | HRH3ALDH1A1KDM4EHRH4 | |
| SCHEMBL1935806 | 0.78 | HRH3 (0.67) | HRH3ALDH1A1KDM4EHRH4SMN1; SMN2 | |
| SCHEMBL14847024 | 0.78 | HRH3 (0.67) | HRH3ALDH1A1KDM4EHRH4SMN1; SMN2 | |
| SCHEMBL12836132 | 0.78 | MAPT (0.48) | ALDH1A1KDM4EHTTSMN1; SMN2HDAC6 | |
| SCHEMBL27474040 | 0.77 | ACHE (0.42) | HTT | |
| SCHEMBL10178474 | 0.77 | HRH3 (0.59) | HRH3ALDH1A1KDM4EHRH4 | |
| SCHEMBL11139655 | 0.76 | HRH3 (0.69) | HRH3ALDH1A1KDM4EHRH4HTT | |
| SCHEMBL2883579 | 0.76 | HRH3 (0.56) | HRH3ALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817294-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006019975-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |