Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729439 | 0.76 | ADORA3 (0.40) | CHEK1KDM4ETDP1ALDH1A1HPGD | |
| SCHEMBL729000 | 0.75 | ADORA3 (0.41) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL731128 | 0.74 | CHEK1 (0.55) | CHEK1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL28250510 | 0.72 | MEN1 (0.43) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL29868109 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1HPGDPOLBTSHR | |
| SCHEMBL9530036 | 0.69 | POLB (0.67) | KDM4EALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL9698674 | 0.66 | MEN1 (0.60) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6601304 | 0.65 | PARP14 (0.46) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL28803380 | 0.65 | POLB (0.56) | KDM4EALDH1A1KMT2APARP1POLB | |
| SCHEMBL1895662 | 0.64 | ALDH1A1 (0.44) | KDM4ETDP1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863813-A2 | PYRAZOLO[3,4-C]QUINOLINES, PYRAZOLO[3,4-C]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107771-A2 | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |