Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.64 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.63 |
| ▸ | CCR6 | P51684 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.63 |
| ▸ | XBP1 | P17861 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512905 | 1.00 | VCP (0.65) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL1411603 | 0.93 | VCP (0.78) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL7207216 | 0.93 | VCP (0.78) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL2742572 | 0.93 | VCP (0.78) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL15952288 | 0.88 | LMNA (0.67) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL15952287 | 0.88 | LMNA (0.67) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL9692560 | 0.88 | VCP (0.61) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL9692565 | 0.88 | VCP (0.61) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL7999955 | 0.87 | TLR4 (0.67) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL5691263 | 0.84 | TLR4 (0.60) | VCPMAPTSMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037813-A1 | Serine Protease Inhibitors | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| EP-1144373-B1 | SERINE PROTEASE INHIBITORS | GENENTECH INC (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20050186198-A1 | Serine protease inhibitors | GENENTECH, INC. | 2005-08-25 | — | — | US | disclosed |
| US-6919369-B2 | Controlling blood coagulation | GENENTECH, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030212071-A1 | Serine protease inhibitors | GENENTECH, INC. | 2003-11-13 | — | — | US | disclosed |
| US-6472393-B1 | Serine protease inhibitors | GENENTECH, INC. | 2002-10-29 | — | — | US | disclosed |
| EP-1144373-A3 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1144373-A2 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041531-A2 | SERINE PROTEASE INHIBITORS | GENENTECH, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212071-A1 | Serine protease inhibitors | SERPINE1, SPINT2, TFPI | VCP 2441/4885MAPT 4012/4885SMN1; SMN2 4178/4885 |
| US-20070037813-A1 | Serine Protease Inhibitors | TFPI, SPINT2, SERPINE1 | VCP 2295/4885MAPT 3882/4885SMN1; SMN2 4351/4885 |
| US-20050186198-A1 | Serine protease inhibitors | TFPI, SPINT2, SERPINE1 | VCP 2295/4885MAPT 3882/4885SMN1; SMN2 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.