Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 5/20 | 0.78 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | GALR2 | O43603 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | NSD2 | O96028 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2742572 | 1.00 | VCP (0.78) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1411603 | 0.94 | VCP (0.78) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5512905 | 0.93 | VCP (0.65) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5512902 | 0.93 | VCP (0.65) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2742571 | 0.89 | VCP (0.74) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11232085 | 0.89 | VCP (0.74) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL793160 | 0.88 | VCP (1.00) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29727003 | 0.88 | VCP (1.00) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL807768 | 0.88 | VCP (1.00) | VCPMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27441155 | 0.87 | VCP (0.70) | VCPMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882021-B1 | NEW PHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2003-03-05 | — | — | EP | disclosed |
| US-6191138-B1 | THERAPY FOR RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-20 | — | — | US | disclosed |