Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.38 |
| ▸ | KDR | P35968 | 10/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479404 | 1.00 | PDGFRB (0.38) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL14276355 | 0.78 | PDGFRB (0.62) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL2342762 | 0.73 | KDR (0.65) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL5550343 | 0.69 | IDO1 (0.45) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL4639795 | 0.69 | IDO1 (0.45) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL26965391 | 0.68 | HCRTR2 (0.39) | MEN1DRD2HTTKMT2A | |
| SCHEMBL30886174 | 0.68 | HCRTR2 (0.39) | MEN1DRD2HTTKMT2A | |
| SCHEMBL15887311 | 0.67 | ACHE (0.44) | MEN1ACHEKMT2A | |
| Trifluoroacetic Acid SCHEMBL5513610 | 0.64 | KDR (0.37) | PDGFRBKDRFGFR1PRKAA1PRKAA2 | |
| SCHEMBL18737178 | 0.64 | MIF (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686987-A4 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
| EP-1686987-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005053614-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | PDGFRB 388/4885KDR 1562/4885FGFR1 1320/4885 |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, HIPK1 | PDGFRB 666/4885KDR 976/4885FGFR1 1586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.