Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28713223 | 0.82 | HPGD (0.63) | HPGDALDH1A1TDP1KDM4ERAB9A | |
| SCHEMBL28958721 | 0.78 | HPGD (0.65) | HPGDALDH1A1TDP1KDM4EHSD17B10 | |
| SCHEMBL1520612 | 0.77 | HPGD (1.00) | HPGDTDP1KDM4ERAB9ANPC1 | |
| SCHEMBL1518767 | 0.77 | MAPK8 (0.69) | HPGDALDH1A1TDP1KDM4EHSD17B10 | |
| SCHEMBL3642839 | 0.76 | MAPT (0.88) | HPGDALDH1A1TDP1KDM4EHSD17B10 | |
| SCHEMBL2807153 | 0.75 | RAB9A (1.00) | HPGDALDH1A1KDM4EHSD17B10RAB9A | |
| SCHEMBL9384187 | 0.73 | NPC1 (0.72) | HPGDALDH1A1KDM4EHSD17B10RAB9A | |
| SCHEMBL21579348 | 0.73 | NPC1 (0.62) | KDM4ERAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16594642 | 0.73 | RAB9A (0.83) | TDP1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27473596 | 0.73 | MEN1 (0.69) | HPGDALDH1A1KDM4EHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39836-E1 | Macrolide antinfective agents | KOSAN BIOSCIENCES, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| CN-1984918-A | Ketolide antibacterials | ORTHO MCNEIL PHARM INC (US) | 2007-06-20 | — | — | CN | disclosed |
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1171446-B1 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES INC (US) | 2006-09-20 | — | — | EP | disclosed |
| CN-1241931-C | Macrolide antinfective agents | KOSAN BIOSCIENCES INC (US) | 2006-02-15 | — | — | CN | disclosed |
| EP-1291351-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1291353-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1291352-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291350-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1345953-A2 | KETOLIDE ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-1171446-A2 | MACROLIDE ANTIINFECTIVE AGENTS | Kosan Biosciences, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1171447-A2 | KETOLIDE ANTIBACTERIALS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6147197-A | INCREASED ACID STABILITY AND ENHANCED ACTIVITY TOWARD GRAM NEGATIVE BACTERIA AND MACROLIDE RESISTANT GRAM POSITIVE BACTERIA | ABBVIE INC. | 2000-11-14 | — | — | US | disclosed |
| WO-2000063224-A2 | MACROLIDE ANTIINFECTIVE AGENTS | KOSAN BIOSCIENCES, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| WO-2000062783-A2 | KETOLIDE ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| US-6075133-A | INCREASED ACID STABILITY AND ENHANCED BACTERICIDAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-06-13 | — | — | US | disclosed |
| US-6028181-A | 6-0-Substituted antibacterial erythromycin ketolides and methods of making | ABBOTT LABORATORIES (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | disclosed |