Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550959 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL2700530 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL550960 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL551508 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL2700526 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL549917 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL549517 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL2701235 | 0.87 | HSD11B1 (0.38) | CYP2D6CYP1A2CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL550534 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL549916 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |