Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550959 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL2700530 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL551507 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL550960 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL2700526 | 1.00 | CYP2D6 (0.43) | CYP2D6HSD17B10ALDH1A1CYP1A2HCRTR2 | |
| SCHEMBL549917 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL549517 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL2701235 | 0.87 | HSD11B1 (0.38) | CYP2D6CYP1A2CYP2C9CYP2C19HSD11B1 | |
| SCHEMBL550534 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 | |
| SCHEMBL549916 | 0.87 | HSD11B1 (0.36) | CYP2D6HSD17B10ALDH1A1HCRTR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | HSD11B1, HSD11B2, HSD17B1 | CYP2D6 204/4885HSD17B10 25/4885ALDH1A1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.