Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.43 |
| ▸ | CTSK | P43235 | 9/20 | 0.43 |
| ▸ | CTSB | P07858 | 6/20 | 0.43 |
| ▸ | CTSL | P07711 | 6/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5519248 | 1.00 | CTSS (0.43) | CTSSCTSKCTSBCTSLASAH1 | |
| SCHEMBL5515090 | 1.00 | CTSS (0.43) | CTSSCTSKCTSBCTSLASAH1 | |
| SCHEMBL5515117 | 0.89 | CTSS (0.40) | CTSSCTSKCTSBCTSLGRM2 | |
| SCHEMBL5515121 | 0.89 | CTSS (0.40) | CTSSCTSKCTSBCTSLGRM2 | |
| SCHEMBL5515127 | 0.89 | CTSS (0.40) | CTSSCTSKCTSBCTSLGRM2 | |
| SCHEMBL5512355 | 0.89 | CTSK (0.47) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5512349 | 0.89 | CTSK (0.47) | CTSSCTSKCTSBCTSL | |
| SCHEMBL5516080 | 0.88 | CYP2D6 (0.43) | ASAH1LSSGRM2CYP2D6HTT | |
| SCHEMBL5516446 | 0.87 | CYP2D6 (0.43) | ASAH1LSSGRM2CYP2D6HTT | |
| SCHEMBL5516441 | 0.87 | CYP2D6 (0.43) | ASAH1LSSGRM2CYP2D6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279478-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2007-10-09 | — | — | US | disclosed |
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | MERCK CANADA INC. (CA) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122268-A1 | Cathepsin cysteine protease inhibitors | CTSB, CTSS, CTSK | CTSS 2/4885CTSK 3/4885CTSB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.