Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551692 | 0.95 | ALDH1A1 (0.56) | GPBAR1ALDH1A1TSHRMAPTHTT | |
| SCHEMBL2178711 | 0.94 | ALDH1A1 (0.52) | GPBAR1ALDH1A1TSHRHPGDMAPT | |
| SCHEMBL7417587 | 0.81 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL2796009 | 0.80 | MAPT (0.69) | GPBAR1ALDH1A1TSHRHPGDMAPT | |
| SCHEMBL13138659 | 0.79 | ALDH1A1 (0.74) | ALDH1A1TSHRHPGDUSP2L3MBTL1 | |
| SCHEMBL3392745 | 0.79 | ALDH1A1 (0.74) | ALDH1A1TSHRHPGDUSP2L3MBTL1 | |
| SCHEMBL552941 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TSHRHPGDUSP2L3MBTL1 | |
| SCHEMBL22179324 | 0.78 | MC4R (0.65) | ALDH1A1POLB | |
| SCHEMBL11769350 | 0.78 | ALDH1A1 (0.53) | ALDH1A1TSHRMAPTHTTLMNA | |
| SCHEMBL3349120 | 0.78 | ALDH1A1 (0.67) | GPBAR1ALDH1A1TSHRHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354406-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-01-15 | — | — | US | disclosed |
| US-20120035164-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-02-09 | — | — | US | disclosed |
| US-8063071-B2 | Chemical compounds | GlaxoSmithKline, LLC (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090143372-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035164-A1 | CHEMICAL COMPOUNDS | IKBKG, NFKBIA, RELA | GPBAR1 1719/4885ALDH1A1 2634/4885TSHR 3204/4885 |
| US-20090143372-A1 | CHEMICAL COMPOUNDS | IKBKG, NFKBIA, RELA | GPBAR1 1719/4885ALDH1A1 2634/4885TSHR 3204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.