Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.40 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.40 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.40 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14544962 | 0.89 | ADORA2A (0.41) | MAPK14MAPK1TLR9TLR8TLR7 | |
| SCHEMBL14545032 | 0.87 | MAPK11 (0.53) | MAPK11MAPK14MAPK1CYP3A4HSD11B1 | |
| SCHEMBL5514358 | 0.86 | LMNA (0.46) | MAPK11MAPK14MAPK1HSD11B1IKBKB | |
| SCHEMBL5524167 | 0.85 | CNR1 (0.42) | MAPK11MAPK14MAPK1HSD11B1IKBKB | |
| SCHEMBL14523445 | 0.84 | MEN1 (0.45) | MAPK11MAPK14MAPK1HSD11B1IKBKB | |
| SCHEMBL5520857 | 0.82 | HSD11B1 (0.41) | MAPK11MAPK14MAPK1HSD11B1IKBKB | |
| SCHEMBL14523443 | 0.80 | MAPT (0.48) | MAPK11MAPK14MAPK1CNR1 | |
| SCHEMBL14545371 | 0.79 | ALDH1A1 (0.47) | CYP3A4CYP3A5ALDH1A1CNR1 | |
| SCHEMBL5514377 | 0.76 | CNR1 (0.46) | MAPK11MAPK14MAPK1HSD11B1CNR1 | |
| SCHEMBL14523442 | 0.75 | CKS1B (0.51) | MAPK11MAPK14MAPK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | NEUROGEN CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | NEUROGEN CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | NEUROGEN CORPORATION (US) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078135-A1 | Substituted heteroaryl CB1 antagonists | CNR1, CNR2, OPRL1 | MAPK11 2957/4885MAPK14 3352/4885MAPK1 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.