Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TOP1 | P11387 | 3/20 | 0.57 |
| ▸ | TOP2A | P11388 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.54 |
| ▸ | TERT | O14746 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.54 |
| ▸ | MELK | Q14680 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843474 | 0.82 | ACHE (0.53) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL14342671 | 0.77 | BRD4 (0.48) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL933054 | 0.77 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL31006250 | 0.76 | FGFR1 (0.76) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL3535921 | 0.76 | FGFR1 (0.76) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL3542379 | 0.76 | FGFR1 (0.76) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL5528791 | 0.76 | RAF1 (0.51) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL3842984 | 0.75 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2HPGDHSD17B10MEN1 | |
| SCHEMBL14656343 | 0.74 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD | |
| SCHEMBL14399402 | 0.74 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2TOP1TOP2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710038-B2 | Pyrazole kinase modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710038-B2 | Pyrazole kinase modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710038-B2 | Pyrazole kinase modulators and methods of use | EXELIXIS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293507-A1 | Pyrazole Kinase Modulators And Methods Of Use | MAP3K1, MAP3K3, MAP3K5 | ALDH1A1 3244/4885SMN1; SMN2 4604/4885TOP1 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.