Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.65 |
| ▸ | NAAA | Q02083 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184062 | 0.99 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL5524028 | 0.99 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL5528312 | 0.83 | HDAC3 (0.55) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL6879226 | 0.83 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL2863808 | 0.81 | GAA (0.61) | NAAAGAA | |
| SCHEMBL24653262 | 0.81 | HDAC1 (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL27339421 | 0.81 | MAPK1 (0.76) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL20684933 | 0.81 | HDAC1 (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL8770694 | 0.81 | MAPK1 (0.76) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL5534324 | 0.81 | HDAC6 (0.53) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015755-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| EP-1452522-A2 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20040147745-A1 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | US | disclosed |
| EP-1178958-B1 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2004-02-18 | — | — | EP | disclosed |
| US-20030096796-A1 | Novel compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2003-05-22 | — | — | US | disclosed |
| US-6455502-B1 | Compounds and compositions as protease inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096796-A1 | Novel compounds and compositions as protease inhibitors | CTRL, SERPINB1, CPN1 | HDAC6 279/4885HDAC1 382/4885HDAC8 571/4885 |
| US-20040147745-A1 | Novel compounds and compositions as protease inhibitors | CTRL, SERPINB1, CPN1 | HDAC6 279/4885HDAC1 382/4885HDAC8 571/4885 |
| US-20070015755-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | CTRL, SERPINB1, CPN1 | HDAC6 279/4885HDAC1 382/4885HDAC8 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.