SCHEMBL5527768

SCHEMBL5527768

O=C(O)C(I)Cc1ccc2ccc3cccc4ccc1c2c34

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.55
▸ MEN1 O00255 2/20 0.55
▸ ALDH1A1 P00352 6/20 0.44
▸ HPGD P15428 5/20 0.44
▸ KDM4E B2RXH2 4/20 0.44
▸ HSD17B10 Q99714 4/20 0.44
▸ CYP1A2 P05177 4/20 0.44
▸ POLB P06746 2/20 0.44
▸ FAAH O00519 1/20 0.44
▸ GLA P06280 1/20 0.44
▸ CYP2D6 P10635 1/20 0.44
▸ HTT P42858 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ CTNNB1 P35222 1/20 0.38
▸ CYP3A4 P08684 2/20 0.37
▸ TSHR P16473 2/20 0.37
▸ TDP1 Q9NUW8 2/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ PPARD Q03181 1/20 0.36
▸ PPARA Q07869 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7111827 0.86 KMT2A (0.50) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL1072482 0.81 KMT2A (0.55) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL28879239 0.81 KMT2A (0.55) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL22122444 0.81 KMT2A (0.55) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL17903512 0.78 KMT2A (0.51) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL28094778 0.77 KMT2A (0.50) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL28094779 0.77 KMT2A (0.50) KMT2AMEN1ALDH1A1HPGDKDM4E
Water SCHEMBL28094441 0.76 KMT2A (0.49) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL1275568 0.75 KMT2A (0.68) KMT2AMEN1ALDH1A1HPGDKDM4E
SCHEMBL29521196 0.75 KMT2A (0.68) KMT2AMEN1ALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10851403-B2 Cyclin-dependent kinase substrate SYSMEX CORPORATION (JP) 2020-12-01 — — US disclosed
US-20180334702-A1 CYCLIN-DEPENDENT KINASE SUBSTRATE SYSMEX CORPORATION (JP) 2018-11-22 — — US disclosed
EP-3404038-A1 CYCLIN-DEPENDENT KINASE SUBSTRATE SYSMEX CORPORATION (JP) 2018-11-21 — — EP disclosed
US-8309298-B2 Method for detecting protein SYSMEX CORPORATION (JP) 2012-11-13 — — US disclosed
US-20070264624-A1 METHOD FOR DETERMINING ACTIVITY OF CELL CYCLE REGULATORY FACTOR AND METHOD FOR DIAGNOSING CANCER USING THE SAME ISHIHARA HIDEKI 2007-11-15 — — US disclosed
US-20070105177-A1 Method for detecting analyte in sample, method for quantifying activity of enzyme, and method for quantifying protein in sample SYSMEX CORPORATION 2007-05-10 — — US disclosed
EP-1767943-A2 Method for detecting analyte in sample Sysmex Corporation (JP) 2007-03-28 — — EP disclosed
WO-1994002640-A1 MULTI REPORTER-LABELED NUCLEIC ACID PROBES APROGENEX, INC. (US) 1994-02-03 — — WO disclosed
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