Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912170 | 0.81 | ALDH1A1 (0.40) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL3123660 | 0.79 | NOTUM (0.39) | NOTUM | |
| SCHEMBL9781917 | 0.79 | ALDH1A1 (0.40) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL8166868 | 0.79 | NPSR1 (0.37) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL417979 | 0.79 | NPSR1 (0.37) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL11076055 | 0.79 | FAAH (0.46) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL22515797 | 0.77 | FAAH (0.36) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL29654087 | 0.76 | NPSR1 (0.35) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL30016924 | 0.76 | NPSR1 (0.36) | NPSR1FAAHNAAAALDH1A1POLB | |
| SCHEMBL8718626 | 0.75 | FAAH (0.39) | NPSR1FAAHNAAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116239578-A | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs | 中国海洋大学 | 2023-06-09 | — | — | CN | claimed |
| CN-101255139-B | Method for synthesizing antitumor compound of diketopiperazine PJ147 | UNIV SHENYANG PHARMACEUTICAL | 2012-11-07 | — | — | CN | claimed |
| CN-101255139-A | Method for synthesizing antitumor compound of diketopiperazine PJ147 | UNIV SHENYANG PHARMACEUTICAL (CN) | 2008-09-03 | — | — | CN | claimed |
| CN-116239578-B | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs | 中国海洋大学 | 2024-09-13 | — | — | CN | disclosed |
| CN-116239578-B | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs | 中国海洋大学 | 2024-09-13 | — | — | CN | disclosed |
| CN-116239578-A | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs | 中国海洋大学 | 2023-06-09 | — | — | CN | disclosed |
| CN-116239578-A | Piperazine dione ring compound, synthesis method thereof and application thereof in preparation of antitumor drugs | 中国海洋大学 | 2023-06-09 | — | — | CN | disclosed |
| EP-2947085-B1 | OXAZOLIDONE COMPOUNDS, METHOD FOR PREPARING AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2017-09-13 | — | — | EP | disclosed |
| CN-101255139-B | Method for synthesizing antitumor compound of diketopiperazine PJ147 | UNIV SHENYANG PHARMACEUTICAL | 2012-11-07 | — | — | CN | disclosed |
| CN-101255139-A | Method for synthesizing antitumor compound of diketopiperazine PJ147 | UNIV SHENYANG PHARMACEUTICAL (CN) | 2008-09-03 | — | — | CN | disclosed |
| EP-0815111-B1 | ANALOGUES OF N-ACETYLARDEEMIN, METHOD OF PREPARATION AND USES THEREOF | UNIV COLUMBIA (US) | 2007-10-10 | — | — | EP | disclosed |
| US-6147076-A | ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2000-11-14 | — | — | US | disclosed |
| WO-1997018215-A9 | ANALOGUES OF N-ACETYLARDEEMIN, METHOD OF PREPARATION AND USES THEREOF | — | 1997-11-06 | — | — | WO | disclosed |
| US-5214145-A | Trisubstituted piperazin-2,5-diones | EASTMAN KODAK COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| US-4992552-A | Process for preparation of amino acids | EASTMAN KODAK COMPANY (US) | 1991-02-12 | — | — | US | disclosed |