Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.59 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 6/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516018 | 0.88 | MAPT (0.58) | LMNAHTTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5531762 | 0.86 | ALDH1A1 (0.56) | LMNAHTTSMN1; SMN2PTBP1KLF5 | |
| SCHEMBL28132033 | 0.78 | L3MBTL1 (0.72) | LMNAHTTSMN1; SMN2PTBP1KLF5 | |
| SCHEMBL4356226 | 0.77 | ALDH1A1 (0.61) | LMNAHTTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24621241 | 0.77 | MAP2K1 (0.47) | HTTSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL876563 | 0.76 | CHRNA7 (0.48) | LMNAHTTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6669304 | 0.75 | HTT (1.00) | LMNAHTTSMN1; SMN2PTBP1KLF5 | |
| SCHEMBL4890102 | 0.74 | CHRNA7 (0.48) | LMNAHTTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL844336 | 0.74 | BCL2L1 (0.53) | LMNAL3MBTL1NAMPTMEN1KMT2A | |
| SCHEMBL4964101 | 0.73 | HTT (0.97) | LMNAHTTSMN1; SMN2PTBP1KLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | MAP4K2, CNKSR1, MAP3K1 | LMNA 3712/4885HTT 4517/4885SMN1; SMN2 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.