SCHEMBL5531

SCHEMBL5531

COc1ccc(N2CC[C@]3(CC[C@@H](Oc4ccccc4)CC3)C2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 14/20 0.50
USP2 O75604 12/20 0.50
CYP2C9 P11712 9/20 0.50
ALDH1A1 P00352 9/20 0.50
CYP2C19 P33261 7/20 0.50
MAPK1 P28482 7/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
CYP1A2 P05177 8/20 0.49
HIF1A Q16665 6/20 0.49
HSD17B10 Q99714 5/20 0.49
SMN1; SMN2 Q16637 8/20 0.49
TSHR P16473 5/20 0.49
HPGD P15428 2/20 0.49
CYP2D6 P10635 2/20 0.47
TP53 P04637 1/20 0.47
FFAR4 Q5NUL3 1/20 0.43
HBB P68871 1/20 0.42
ALOX15 P16050 2/20 0.41
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4072452 0.74 CYP3A4 (0.55) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL23412145 0.74 ADRB1 (0.61) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL1589331 0.74 EGLN1 (0.44) MAPK1MEN1KMT2ASMN1; SMN2MAPT
SCHEMBL10269 0.74 EGLN1 (0.44) MAPK1MEN1KMT2ASMN1; SMN2MAPT
SCHEMBL10270 0.74 EGLN1 (0.44) MAPK1MEN1KMT2ASMN1; SMN2MAPT
SCHEMBL4072450 0.74 CYP3A4 (0.63) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
Hydrochloric Acid SCHEMBL23411807 0.73 ADRB1 (0.59) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
Hydrochloric Acid SCHEMBL23411806 0.72 HTR3E (0.58) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL14996536 0.71 HTR3E (0.51) CYP3A4USP2CYP2C9ALDH1A1CYP2C19
SCHEMBL22365580 0.70 USP2 (0.49) CYP3A4USP2CYP2C9ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488493-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-08-22 EP disclosed
WO-2011045292-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 WO disclosed