Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.52 |
| ▸ | TSHR | P16473 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.52 |
| ▸ | USP2 | O75604 | 7/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23412145 | 0.97 | ADRB1 (0.61) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL23411807 | 0.96 | ADRB1 (0.59) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL1426554 | 0.89 | USP2 (0.56) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL23411980 | 0.85 | ADRB1 (0.61) | ADRB1CYP3A4CYP2D6TSHRALDH1A1 | |
| SCHEMBL485421 | 0.82 | ADRB1 (0.61) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL23411476 | 0.82 | ADRB1 (0.64) | ADRB1CYP3A4CYP2D6TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL29933090 | 0.81 | ADRB1 (0.62) | ADRB1CYP3A4CYP2D6TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL23411981 | 0.81 | ADRB1 (0.62) | ADRB1CYP3A4CYP2D6TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL23411802 | 0.80 | CYP2D6 (0.77) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL939303 | 0.77 | CYP3A4 (0.82) | CYP3A4CYP2D6TSHRALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230064809-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-03-02 | — | — | US | disclosed |
| WO-2021105116-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230064809-A1 | SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION | DGKK, DGKG, DGKA | HTR3E 4193/4885HTR3B 4068/4885ADRB1 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.