Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108678 | 0.87 | KDM4E (0.70) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL3026991 | 0.85 | KDM4E (0.58) | CYP2D6PKMKDM4EMEN1USP2 | |
| SCHEMBL19300185 | 0.83 | CYP2D6 (0.63) | CYP2D6PKMKDM4EMEN1USP2 | |
| SCHEMBL2316901 | 0.83 | CYP2D6 (0.82) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL4753138 | 0.82 | MEN1 (0.66) | CYP2D6PKMKDM4EMEN1USP2 | |
| SCHEMBL8170046 | 0.81 | KDM4E (0.62) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL8286300 | 0.80 | KDM4E (0.62) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL13062752 | 0.80 | ALDH1A1 (0.64) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL22005473 | 0.80 | KDM4E (0.62) | CYP2D6KDM4EMEN1USP2CYP1A2 | |
| SCHEMBL19300219 | 0.80 | KDM4E (0.62) | CYP2D6KDM4EMEN1USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776936-A | Marcfortine/paraherquamide derivatives useful as antiparasitic agents | PHARMACIA & UPJOHN COMPANY (US) | 1998-07-07 | — | — | US | claimed |
| EP-1957073-B1 | MEDICINAL DRUG | OTSUKA PHARMA CO LTD (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-7241770-B2 | Hydronopol derivatives as agonists on human ORL1 receptors | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| US-20050131004-A1 | Hydronopol derivatives as agonists on human ORL1 receptors | SOLVAY PHARMACEUTICALS GMBH. | 2005-06-16 | — | — | US | disclosed |
| US-5776936-A | Marcfortine/paraherquamide derivatives useful as antiparasitic agents | PHARMACIA & UPJOHN COMPANY (US) | 1998-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131004-A1 | Hydronopol derivatives as agonists on human ORL1 receptors | OPRL1, ORMDL3, OGFRL1 | CYP2D6 1625/4885PKM 4801/4885KDM4E 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.