Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 9/20 | 0.55 |
| ▸ | LAP3 | P28838 | 3/20 | 0.51 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.49 |
| ▸ | GRN | P28799 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levacetylleucine SCHEMBL714003 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Acetylleucine SCHEMBL282371 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Levacetylleucine SCHEMBL9438432 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Levacetylleucine SCHEMBL282372 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Levacetylleucine SCHEMBL5527234 | 0.96 | ALDH1A1 (0.96) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Levacetylleucine SCHEMBL18954336 | 0.96 | ALDH1A1 (0.96) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Levacetylleucine SCHEMBL7923132 | 0.96 | ALDH1A1 (0.96) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| Acetylleucine SCHEMBL25408262 | 0.92 | ALDH1A1 (0.88) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL5551895 | 0.90 | ALDH1A1 (0.85) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL17948650 | 0.90 | ALDH1A1 (0.85) | ALDH1A1MEN1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128468-A | An efficient and stereoselective process for large scale synthesis of 3-(R)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-B}quinolin-9-one | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1851227-A1 | AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-07 | — | — | EP | disclosed |
| US-20070015798-A1 | Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-18 | — | — | US | disclosed |
| WO-2006093719-A1 | AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015798-A1 | Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives | PDE5A, PDE3A, PDE3B | ALDH1A1 1786/4885MEN1 3866/4885LMNA 3225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.