Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805381 | 0.72 | ALDH1A1 (0.50) | HRH3ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20995291 | 0.72 | ALDH1A1 (0.59) | HRH3ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL20995289 | 0.72 | ALDH1A1 (0.59) | HRH3ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL6557590 | 0.68 | HTT (0.47) | HRH3ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL552144 | 0.67 | HRH3 (0.41) | HRH3ALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL552041 | 0.66 | TSHR (0.37) | HRH3POLB | |
| SCHEMBL27266438 | 0.66 | HRH3 (0.67) | HRH3ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL13291354 | 0.65 | ALDH1A1 (0.63) | HRH3ALDH1A1KDM4EPOLBLTA4H | |
| SCHEMBL1357166 | 0.65 | ALDH1A1 (0.63) | HRH3ALDH1A1KDM4EPOLBLTA4H | |
| SCHEMBL3355426 | 0.65 | ALDH1A1 (0.63) | HRH3ALDH1A1KDM4EPOLBLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354406-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-01-15 | — | — | US | disclosed |
| US-20120035164-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-02-09 | — | — | US | disclosed |
| US-8063071-B2 | Chemical compounds | GlaxoSmithKline, LLC (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090143372-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1896014-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005534-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035164-A1 | CHEMICAL COMPOUNDS | IKBKG, NFKBIA, RELA | HRH3 568/4885ALDH1A1 2634/4885KDM4E 1113/4885 |
| US-20090143372-A1 | CHEMICAL COMPOUNDS | IKBKG, NFKBIA, RELA | HRH3 568/4885ALDH1A1 2634/4885KDM4E 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.