SCHEMBL5532233

SCHEMBL5532233

C1=CC2C(=C1)Oc1ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
ATM Q13315 1/20 0.36
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34
KCNA3 P22001 1/20 0.33
CYP2C9 P11712 1/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9844880 0.72 MAOA (0.38) MAOAMAOBATMHDAC3HDAC4
SCHEMBL21042809 0.71 ENPP2 (0.31)
SCHEMBL15012589 0.71 CYP2C9 (0.40) MAOAMAOBATMHDAC3HDAC4
SCHEMBL21041341 0.71
SCHEMBL25998053 0.70 MAOA (0.33) MAOAMAOBKCNA3CYP2C9
SCHEMBL14200341 0.68 MAOA (0.38) MAOAMAOBATMHDAC3HDAC4
SCHEMBL15624403 0.68 MEN1 (0.40) MAOAMAOBATMHDAC3HDAC4
SCHEMBL10583660 0.68 AHR (0.30)
SCHEMBL21041345 0.67
SCHEMBL271402 0.67 CYP2C9 (0.44) MAOAMAOBATMHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007007937-A1 TRICYCLIC TETRAHYDROFURAN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2007-01-18 WO disclosed