Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17943821 | 0.74 | CYP2C9 (0.42) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL5532233 | 0.72 | MAOA (0.42) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL9693192 | 0.70 | CYP2C9 (0.40) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL3236129 | 0.65 | MAOA (0.58) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL29844073 | 0.65 | ALOX15 (0.36) | MAOBMEN1KMT2ATSHRMAPT | |
| SCHEMBL271402 | 0.63 | CYP2C9 (0.44) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL5668650 | 0.63 | CYP2C9 (0.44) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL9844971 | 0.63 | CYP2C9 (0.34) | MAOAMAOBCYP2C9ATMMEN1 | |
| SCHEMBL18568246 | 0.62 | ATM (0.42) | MAOAMAOBCYP2C9ATMHDAC3 | |
| SCHEMBL20785354 | 0.60 | MAOA (0.46) | MAOAMAOBCYP2C9ATMHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420571-A2 | 6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4978679-A | 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO., INC. (US) | 1990-12-18 | — | — | US | disclosed |