Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL15795939 | 0.91 | APLNR (0.41) | APLNRCYP2C19CYP1A2ALOX15KDM4E | |
| SCHEMBL15804441 | 0.82 | APLNR (0.33) | APLNRCYP2C19MAPK1PMP22LMNA | |
| SCHEMBL21434917 | 0.78 | APLNR (0.52) | APLNRCYP2C19CYP1A2ALOX15KDM4E | |
| SCHEMBL19550863 | 0.78 | APLNR (0.52) | APLNRCYP2C19CYP1A2ALOX15KDM4E | |
| SCHEMBL21434918 | 0.78 | APLNR (0.52) | APLNRCYP2C19CYP1A2ALOX15KDM4E | |
| SCHEMBL26535538 | 0.78 | APLNR (0.31) | APLNRHCRTR2HCRTR1MAPT | |
| SCHEMBL4184435 | 0.78 | GAA (0.35) | APLNRALOX15KDM4EPMP22LMNA | |
| SCHEMBL25215367 | 0.78 | SMN1; SMN2 (0.38) | APLNRALDH1A1SMN1; SMN2 | |
| SCHEMBL30237791 | 0.76 | CHRNB2 (0.34) | APLNRCYP2C19KDM4EMAPK1PMP22 | |
| SCHEMBL32677648 | 0.76 | SLC1A2 (0.36) | APLNRCYP2C19KDM4EMAPK1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44768-E1 | Rapamycin hydroxyesters | WYETH LLC (US) | 2014-02-18 | — | — | US | claimed |
| EP-1760083-A1 | Rapamycin hydroxyesters, process for their preparation and pharmaceutical compositions containing them | Wyeth (US) | 2007-03-07 | — | — | EP | claimed |
| EP-1266899-B1 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | WYETH CORP (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1266899-A2 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | Wyeth (US) | 2002-12-18 | — | — | EP | claimed |
| EP-0763039-A1 | RAPAMYCIN HYDROXYESTERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-19 | — | — | EP | claimed |
| WO-1995028406-A1 | RAPAMYCIN HYDROXYESTERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-26 | — | — | WO | claimed |
| US-5362718-A | Rapamycin hydroxyesters | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | claimed |
| US-20230321284-A1 | COMPOUND, CONTRAST AGENT, AND METHOD FOR PRODUCING COMPOUND | ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE (JP) | 2023-10-12 | — | — | US | disclosed |
| US-20230321284-A1 | COMPOUND, CONTRAST AGENT, AND METHOD FOR PRODUCING COMPOUND | ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE (JP) | 2023-10-12 | — | — | US | disclosed |
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| CN-103992222-B | Acrylic monomer, polymer, and resist composition containing the polymer | 锦湖石油化学株式会社 | 2016-08-24 | — | — | CN | disclosed |
| EP-1760083-A1 | Rapamycin hydroxyesters, process for their preparation and pharmaceutical compositions containing them | Wyeth (US) | 2007-03-07 | — | — | EP | disclosed |
| EP-1266899-B1 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | WYETH CORP (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1266899-A2 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | APLNR 3591/4885CYP2C19 999/4885CYP1A2 2284/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | APLNR 3591/4885CYP2C19 999/4885CYP1A2 2284/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | APLNR 3591/4885CYP2C19 999/4885CYP1A2 2284/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | APLNR 3591/4885CYP2C19 999/4885CYP1A2 2284/4885 |
| US-20230321284-A1 | COMPOUND, CONTRAST AGENT, AND METHOD FOR PRODUCING COMPOUND | RXFP1, AVPR2, RXFP3 | APLNR 1684/4885CYP2C19 2707/4885CYP1A2 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.