Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13744823 | 0.85 | KMT2A (0.52) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL117704 | 0.82 | TDP1 (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL30445640 | 0.82 | TDP1 (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL4864791 | 0.82 | TDP1 (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| SCHEMBL3165661 | 0.82 | LMNA (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| SCHEMBL11642798 | 0.82 | LMNA (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL29525126 | 0.82 | TDP1 (0.65) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| SCHEMBL1117054 | 0.81 | LMNA (0.50) | LMNATDP1L3MBTL1TSHRALDH1A1 | |
| SCHEMBL15040607 | 0.80 | ALDH1A1 (0.52) | LMNAL3MBTL1ALDH1A1SMN1; SMN2RAB9A | |
| 2,4,5-Trichlorophenoxyacetic Acid SCHEMBL4586268 | 0.80 | TDP1 (0.62) | LMNATDP1L3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | LMNA 2932/4885TDP1 1807/4885L3MBTL1 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.