Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582352 | 0.86 | LMNA (0.53) | LMNAMAPTTP53KMT2ATHRB | |
| SCHEMBL2588877 | 0.75 | KMT2A (0.54) | LMNAMAPTTP53KMT2ATHRB | |
| Hydrochloric Acid SCHEMBL2585132 | 0.74 | KMT2A (0.53) | LMNAMAPTTP53KMT2ATHRB | |
| SCHEMBL2585782 | 0.74 | MAPT (0.48) | LMNAMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL5527557 | 0.71 | MAPT (0.46) | LMNAMAPTTP53KMT2ATHRB | |
| SCHEMBL5531337 | 0.70 | USP2 (0.38) | LMNAMAPTTP53KMT2ATHRB | |
| SCHEMBL1481563 | 0.68 | GPR119 (0.78) | LMNAMAPTKMT2AALDH1A1GPR119 | |
| SCHEMBL3441391 | 0.67 | KMT2A (0.57) | LMNAMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL22481977 | 0.66 | USP2 (0.42) | MAPTKMT2AALDH1A1USP2POLB | |
| SCHEMBL4716468 | 0.66 | GPR119 (0.42) | LMNAMAPTTP53KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869053-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| EP-1869053-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105945-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-10-12 | — | — | WO | disclosed |