SCHEMBL5533864

SCHEMBL5533864

O=C(O)Oc1noc2c1CN(S(=O)(=O)c1ccc(F)cc1)CC2

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
PKM P14618 4/20 0.41
KDM4E B2RXH2 3/20 0.40
AKR1C3 P42330 2/20 0.39
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
PKLR P30613 1/20 0.38
GAA P10253 1/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA4 P43681 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5531185 0.90 MEN1 (0.45) MEN1KMT2APKMAKR1C3L3MBTL1
SCHEMBL5529341 0.87 PKM (0.47) PKMKDM4EAKR1C3L3MBTL1PKLR
SCHEMBL5531317 0.87 AKR1C3 (0.43) MEN1KMT2AAKR1C3
SCHEMBL4261182 0.83 MEN1 (0.47) MEN1KMT2APKMKDM4EAKR1C3
SCHEMBL5539142 0.82 AKR1C3 (0.46) MEN1KMT2AAKR1C3GAAALDH1A1
SCHEMBL5533718 0.82 LMNA (0.46) PKMKDM4EAKR1C3MAPTL3MBTL1
SCHEMBL5243723 0.79 TSHR (0.47) MEN1KMT2APKMALDH1A1POLB
SCHEMBL5531260 0.77 ALDH1A1 (0.45) MEN1KMT2APKMKDM4EMAPT
SCHEMBL5528830 0.76 CHRM3 (0.39) L3MBTL1GAAALDH1A1
SCHEMBL15062759 0.75 CHRM3 (0.38) MEN1KMT2AKDM4EAKR1C3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP disclosed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO disclosed