Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27264919 | 0.79 | HTT (0.64) | RAB9APOLBKMT2ANPC1ABCC1 | |
| SCHEMBL5534327 | 0.78 | RAB9A (0.65) | RAB9APOLBKMT2ANPC1ABCC1 | |
| SCHEMBL18615457 | 0.77 | EPHX2 (0.63) | RAB9APOLBKMT2AMEN1TSHR | |
| SCHEMBL5533077 | 0.76 | RAB9A (0.70) | RAB9APOLBKMT2ANPC1ABCC1 | |
| SCHEMBL5531644 | 0.75 | EPHX2 (0.62) | RAB9APOLBKMT2AMEN1NPC1 | |
| SCHEMBL5531779 | 0.74 | PDK2 (0.53) | RAB9APOLBKMT2AMEN1TSHR | |
| SCHEMBL12126017 | 0.73 | MEN1 (0.60) | KMT2AMEN1TSHRATMTMPRSS4 | |
| SCHEMBL30977684 | 0.73 | MEN1 (0.60) | KMT2AMEN1TSHRATMTMPRSS4 | |
| SCHEMBL12518235 | 0.73 | ALDH1A1 (0.56) | KMT2AMEN1TSHRTMPRSS4CA12 | |
| SCHEMBL3618813 | 0.72 | MEN1 (0.61) | KMT2AMEN1TSHRDGAT1TMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | RAB9A 902/4885POLB 4518/4885KMT2A 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.