Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2193334 | 0.84 | PDK2 (0.47) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL4987570 | 0.81 | ALDH1A1 (0.46) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL1788233 | 0.80 | TSHR (0.57) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL4967948 | 0.79 | ALDH1A1 (0.42) | TSHRALDH1A1HSD17B10KDM4EATM | |
| Ammonia Solution, Strong SCHEMBL28371090 | 0.79 | TSHR (0.55) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL24895044 | 0.78 | NR4A2 (0.47) | TSHRALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL31676878 | 0.76 | SLC6A3 (0.58) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL23354388 | 0.76 | SLC6A3 (0.58) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL22745916 | 0.76 | LMNA (0.52) | TSHRLMNAALDH1A1HSD17B10CFTR | |
| SCHEMBL10938198 | 0.75 | TSHR (0.55) | TSHRLMNAALDH1A1HSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828147-A1 | QUINOXALINES AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006040568-A1 | QUINOXALINES AS B RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |