Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1D | Q01668 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003408 | 0.82 | MAPT (0.41) | MAPTKMT2AACHE | |
| SCHEMBL10929590 | 0.74 | HTR2A (0.46) | KDM4EMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31299804 | 0.69 | ALDH1A1 (0.49) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL3142647 | 0.69 | KDM4E (0.52) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL7890630 | 0.67 | MAPT (0.53) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL12994290 | 0.67 | LMNA (0.66) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL10542632 | 0.66 | CACNA1D (0.55) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL9602040 | 0.65 | CACNA1D (0.57) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL10275885 | 0.63 | KDM4E (0.42) | CACNA1DKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL29437308 | 0.61 | ALDH1A1 (0.67) | HSD17B10ALDH1A1TDP1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |