Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 10/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 18/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1635258 | 0.80 | NR3C1 (0.42) | HTR2AHTR2CHTR2BNR3C2NR3C1 | |
| SCHEMBL4816885 | 0.70 | NR3C1 (0.40) | HTR2AHTR2CHTR2BNR3C2NR3C1 | |
| SCHEMBL1633723 | 0.68 | HTR2A (0.42) | HTR2AHTR2CHTR2BNR3C2NR3C1 | |
| SCHEMBL19205409 | 0.68 | SIGMAR1 (0.47) | HTR2AHTR2CHTR2B | |
| SCHEMBL1775217 | 0.68 | NR3C1 (0.71) | NR3C2NR3C1 | |
| SCHEMBL1634952 | 0.68 | NR3C1 (0.71) | NR3C2NR3C1 | |
| SCHEMBL23232573 | 0.67 | HTR2A (0.52) | HTR2AHTR2CHTR2B | |
| SCHEMBL30741563 | 0.67 | HTR2A (0.52) | HTR2AHTR2CHTR2B | |
| SCHEMBL1634501 | 0.67 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2BNR3C2NR3C1 | |
| SCHEMBL6178145 | 0.65 | SIGMAR1 (0.68) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268152-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-09-11 | — | — | US | disclosed |