Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256920 | 0.89 | ATM (0.44) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL22257222 | 0.88 | TRPV1 (0.45) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL22257004 | 0.85 | SLCO1B1 (0.54) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL5539079 | 0.82 | ATM (0.56) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL24287636 | 0.81 | ATM (0.38) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL22256587 | 0.80 | SLCO1B1 (0.68) | ATMABCC1RAB9ANPC1MAPT | |
| SCHEMBL4200801 | 0.79 | KDM4E (0.58) | RAB9ANPC1MAPTKDM4ELPAR1 | |
| SCHEMBL5772191 | 0.77 | LPAR1 (0.57) | RAB9AMAPTKDM4ELPAR1LPAR3 | |
| SCHEMBL4035675 | 0.77 | MAPT (0.67) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL22256922 | 0.75 | SLCO1B1 (0.55) | ATMMAPTLPAR1LPAR3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | ATM 2072/4885ABCC1 2977/4885RAB9A 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.