Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.57 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035675 | 0.82 | MAPT (0.67) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL5529169 | 0.78 | MAPT (0.62) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL5537590 | 0.77 | ATM (0.56) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL5776130 | 0.75 | NTRK1 (0.41) | LPAR1LPAR3KDM4EPTGS1ALDH1A1 | |
| SCHEMBL4029141 | 0.73 | LPAR1 (0.62) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4033791 | 0.73 | LPAR1 (0.52) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL2780170 | 0.72 | LPAR1 (1.00) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL18597735 | 0.72 | LPAR1 (0.57) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL6382 | 0.72 | LPAR1 (0.57) | LPAR1LPAR3MAPTKDM4EABCC3 | |
| SCHEMBL4037272 | 0.72 | MAPT (0.54) | LPAR1LPAR3MAPTKDM4EABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | LPAR1 4480/4885LPAR3 2790/4885MAPT 4701/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | LPAR1 4447/4885LPAR3 4232/4885MAPT 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.