Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5519650 | 1.00 | DRD2 (0.55) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL16524042 | 0.93 | KMT2A (0.52) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL7583988 | 0.93 | DRD2 (0.60) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL27504591 | 0.93 | DRD2 (0.60) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL8749508 | 0.84 | DRD2 (0.51) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL8749510 | 0.84 | DRD2 (0.51) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL8749514 | 0.84 | DRD2 (0.51) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL30772788 | 0.82 | CYP2C9 (0.48) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL19898547 | 0.82 | CYP2C9 (0.48) | DRD2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL3897971 | 0.81 | DRD2 (0.78) | DRD2KMT2AL3MBTL1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | DRD2 54/4885KMT2A 792/4885L3MBTL1 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.