Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812606 | 0.85 | KCNA5 (0.49) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL9005813 | 0.80 | ALDH1A1 (0.51) | TSHRCYP2D6CYP1A2ALDH1A1ADORA2A | |
| SCHEMBL22342850 | 0.80 | POLB (0.50) | KCNA5KCNH2TSHRCYP2D6CYP1A2 | |
| SCHEMBL5349302 | 0.79 | SLC6A2 (0.48) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL27727457 | 0.79 | KCNA5 (0.46) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL6268899 | 0.79 | KCNA5 (0.46) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL11367296 | 0.79 | KCNA5 (0.42) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL19583590 | 0.79 | KCNA5 (0.40) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL29471914 | 0.79 | KCNA5 (0.40) | KCNA5KCNH2TSHRCYP2D6KCNE1 | |
| SCHEMBL13081517 | 0.78 | SLC6A2 (0.47) | KCNA5KCNH2TSHRCYP2D6KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372973-B2 | Prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-02-12 | — | — | US | disclosed |
| US-20120028997-A1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | COATS STEVEN J (US) | 2012-02-02 | — | — | US | disclosed |
| US-7902358-B2 | Gastrointestinal disorders; inflammatory bowel disorders; gastroesophageal reflux, constipation; diarrhea | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-08 | — | — | US | disclosed |
| US-7482359-B2 | Androgen receptor modulators | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20080287445-A1 | Prokineticin 2 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-20 | — | — | US | disclosed |
| US-20080269225-A1 | Prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | US | disclosed |
| US-20070269405-A1 | Androgen Receptor Modulators | MERCK SHARP & DOHME CORP. | 2007-11-22 | — | — | US | disclosed |
| EP-1846419-A2 | ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-10-24 | — | — | EP | disclosed |
| CN-1997656-A | Metal complexes | MERCK PATENT GMBH (DE) | 2007-07-11 | — | — | CN | disclosed |
| WO-2006086449-A2 | ALKYLOXY SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| US-5616613-A | ANTITUMOR AGENTS; ISOMERS; STABLE IN WATER, SOLUBLE FOR INTRAVENOUS INJECTION | TORAY INDUSTRIES, INC. (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0518645-B1 | Platinum (II) complex and antitumor agent | TORAY INDUSTRIES (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0704453-A1 | NOVEL PLATINUM (II) COMPLEX AND REMEDY FOR MALIGNANT TUMOR | TORAY INDUSTRIES, INC. (JP) | 1996-04-03 | — | — | EP | disclosed |
| US-5348950-A | Side effect reduction | TORAY INDUSTRIES, INC. (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0518645-A1 | Platinum (II) complex and antitumor agent | TORAY INDUSTRIES, INC. (JP) | 1992-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028997-A1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | PROKR1, PROKR2, GIPR | KCNA5 2026/4885KCNH2 2397/4885TSHR 228/4885 |
| US-20070269405-A1 | Androgen Receptor Modulators | AR, SHBG, FSHR | KCNA5 4520/4885KCNH2 4263/4885TSHR 503/4885 |
| US-20080269225-A1 | Prokineticin 1 receptor antagonists | PROKR1, PROKR2, GIPR | KCNA5 2026/4885KCNH2 2397/4885TSHR 228/4885 |
| US-20080287445-A1 | Prokineticin 2 receptor antagonists | PROKR2, PROKR1, GIPR | KCNA5 1484/4885KCNH2 1331/4885TSHR 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.