Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5544896 | 0.85 | MEN1 (0.46) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL5546854 | 0.85 | CYP2C19 (0.40) | MAPTLMNARORCKDM4ENPSR1 | |
| SCHEMBL5548489 | 0.80 | TUBB4A (0.50) | MAPTLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL5546835 | 0.78 | FLT1 (0.44) | MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL5546901 | 0.78 | ALDH1A1 (0.51) | MAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL5546600 | 0.77 | KMT2A (0.40) | MAPTLMNARORCKDM4ENPSR1 | |
| SCHEMBL5548545 | 0.77 | SIRT2 (0.42) | MAPTLMNAKMT2AMEN1THRB | |
| SCHEMBL5546201 | 0.75 | ABL1 (0.40) | LMNAKMT2AMEN1 | |
| SCHEMBL5545021 | 0.74 | EPHX2 (0.39) | KMT2AMEN1ALDH1A1THRB | |
| SCHEMBL5545059 | 0.73 | ALDH1A1 (0.46) | LMNAKDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |