Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547353 | 0.93 | CNR2 (0.48) | CNR2CNR1GRIN2BGRIN1POLB | |
| SCHEMBL5545426 | 0.90 | L3MBTL1 (0.42) | CNR2CNR1GRIN2BGRIN1 | |
| SCHEMBL5548658 | 0.90 | CNR2 (0.44) | CNR2CNR1GRIN2BGRIN1POLB | |
| SCHEMBL5545968 | 0.90 | GRIN2B (0.44) | CNR2CNR1GRIN2BGRIN1BRD4 | |
| SCHEMBL5543297 | 0.90 | CNR2 (0.44) | CNR2CNR1GRIN2BGRIN1 | |
| SCHEMBL5547035 | 0.88 | GRIN2B (0.45) | CNR2CNR1GRIN2BGRIN1THRB | |
| SCHEMBL5545482 | 0.88 | GRIN2B (0.42) | CNR2CNR1GRIN2BBRD4 | |
| SCHEMBL5538730 | 0.87 | CNR2 (0.42) | CNR2CNR1GRIN2BGRIN1POLB | |
| SCHEMBL5545873 | 0.87 | L3MBTL1 (0.43) | CNR2CNR1GRIN2BGRIN1THRB | |
| SCHEMBL5539157 | 0.86 | CNR2 (0.49) | CNR2CNR1GRIN2BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256713-A1 | 2-OXONAPHTHYRIDINE-3-CARBOXAMIDES HIV INTEGRASE INHIBITORS | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | claimed |
| EP-1720856-B1 | HIV INTEGRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-08-14 | — | — | EP | claimed |
| US-20070124152-A1 | Hiv Integrase Inhibitors | GLAXOSMITHKLINE LLC | 2007-05-31 | — | — | US | claimed |
| US-20150225399-A1 | HIV INTEGRASE INHIBITORS | VIIV HEALTHCARE CO (US) | 2015-08-13 | — | — | US | disclosed |
| US-20140256713-A1 | 2-OXONAPHTHYRIDINE-3-CARBOXAMIDES HIV INTEGRASE INHIBITORS | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | disclosed |
| EP-1720856-B1 | HIV INTEGRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-08-14 | — | — | EP | disclosed |
| US-20070124152-A1 | Hiv Integrase Inhibitors | GLAXOSMITHKLINE LLC | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256713-A1 | 2-OXONAPHTHYRIDINE-3-CARBOXAMIDES HIV INTEGRASE INHIBITORS | BCDIN3D, DUT, SAMHD1 | CNR2 3954/4885CNR1 4053/4885GRIN2B 1400/4885 |
| US-20150225399-A1 | HIV INTEGRASE INHIBITORS | ING2, API5, SAMHD1 | CNR2 4810/4885CNR1 4670/4885GRIN2B 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.