Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5544608 | 0.75 | NOTUM (0.40) | NOTUMPIK3R1PIK3CAALDH1A1MAPK1 | |
| SCHEMBL197671 | 0.72 | HSD11B1 (0.56) | NOTUMHSD11B1PSMB8CYP1A2CYP3A4 | |
| SCHEMBL1477743 | 0.71 | CYP2A6 (0.46) | NOTUMHSD11B1ALDH1A1HSD17B10TSHR | |
| SCHEMBL3784695 | 0.71 | ALDH1A1 (0.48) | CYP3A4ALDH1A1ALOX15HSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL29010139 | 0.70 | HSD11B1 (0.54) | NOTUMHSD11B1PSMB8CYP1A2CYP3A4 | |
| SCHEMBL8022901 | 0.70 | HSD11B1 (0.54) | NOTUMHSD11B1PSMB8CYP1A2CYP3A4 | |
| SCHEMBL16401835 | 0.69 | PIK3R1 (0.56) | NOTUMHSD11B1PSMB8PIK3R1PIK3CA | |
| SCHEMBL3636361 | 0.69 | HSD11B1 (0.42) | NOTUMSCN9AHSD11B1PSMB8CYP1A2 | |
| SCHEMBL1369845 | 0.69 | HSD11B1 (0.42) | NOTUMSCN9AHSD11B1PSMB8CYP1A2 | |
| SCHEMBL2205009 | 0.69 | NOTUM (0.44) | NOTUMSCN9AHSD11B1PSMB8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634400-B2 | Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents | UNIVERSITY OF ROCHESTER (US) | 2023-04-25 | — | — | US | claimed |
| US-20200277270-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER | 2020-09-03 | — | — | US | claimed |
| WO-2019040335-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER (US) | 2019-02-28 | — | — | WO | claimed |
| US-20160115508-A1 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2016-04-28 | — | — | US | claimed |
| EP-3003317-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | University Of Rochester (US) | 2016-04-13 | — | — | EP | claimed |
| WO-2014197591-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | UNIVERSITY OF ROCHESTER (US) | 2014-12-11 | — | — | WO | claimed |
| US-11634400-B2 | Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents | UNIVERSITY OF ROCHESTER (US) | 2023-04-25 | — | — | US | disclosed |
| US-20200277270-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER | 2020-09-03 | — | — | US | disclosed |
| WO-2019040335-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | UNIVERSITY OF ROCHESTER (US) | 2019-02-28 | — | — | WO | disclosed |
| US-20160115508-A1 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2016-04-28 | — | — | US | disclosed |
| EP-3003317-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | University Of Rochester (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014197591-A2 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | UNIVERSITY OF ROCHESTER (US) | 2014-12-11 | — | — | WO | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | NOTUM 3827/4885SCN9A 3612/4885HSD11B1 256/4885 |
| US-11634400-B2 | Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents | TNF, C9, CYP51A1 | NOTUM 319/4885SCN9A 4579/4885HSD11B1 106/4885 |
| US-20200277270-A1 | MICHELIOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AND ANTIINFLAMMATORY AGENTS | TNF, C9, CYP51A1 | NOTUM 319/4885SCN9A 4579/4885HSD11B1 106/4885 |
| US-20160115508-A1 | PARTHENOLIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTICANCER AGENTS | CYP3A43, POR, CYP3A4 | NOTUM 99/4885SCN9A 4005/4885HSD11B1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.