Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11922838 | 0.81 | LMNA (0.41) | LMNACA12CA1CA2CA9 | |
| SCHEMBL5541518 | 0.75 | ALDH1A1 (0.47) | LMNA | |
| SCHEMBL18907822 | 0.74 | MMP8 (0.34) | MMP8 | |
| SCHEMBL10266048 | 0.73 | TET2 (0.47) | LMNACA12CA1CA2CA9 | |
| SCHEMBL19981641 | 0.73 | ALDH1A1 (0.46) | LMNACA12CA1CA2CA9 | |
| SCHEMBL5541412 | 0.72 | PIK3CD (0.33) | LMNA | |
| SCHEMBL24869141 | 0.70 | LMNA (0.46) | LMNACA12CA1CA2CA9 | |
| SCHEMBL18909748 | 0.69 | CYP2D6 (0.50) | HSD17B10MMP8 | |
| SCHEMBL13712976 | 0.69 | LMNA (0.44) | LMNACA12CA1CA2CA9 | |
| SCHEMBL23197920 | 0.68 | EPHX1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367666-B2 | 3-carbamoyl-2-pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |