Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.50 |
| ▸ | GSK3A | P49840 | 14/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5543524 | 0.89 | ADORA1 (0.43) | GSK3BGSK3AADORA1GPR84 | |
| SCHEMBL5549402 | 0.89 | ADORA1 (0.43) | GSK3BGSK3AADORA1MAPTGPR84 | |
| SCHEMBL3528033 | 0.88 | GSK3B (0.56) | GSK3BGSK3AADORA1 | |
| SCHEMBL5545429 | 0.88 | GSK3B (0.46) | GSK3BGSK3AADORA1TP53MAPT | |
| SCHEMBL5549014 | 0.87 | CA1 (0.49) | ADORA1RXFP1SMN1; SMN2 | |
| SCHEMBL5545525 | 0.85 | ADORA1 (0.47) | GSK3BGSK3AADORA1 | |
| SCHEMBL3526786 | 0.85 | GSK3B (0.56) | GSK3BGSK3AADORA1 | |
| SCHEMBL5549261 | 0.84 | KMT2A (0.48) | RXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL5545556 | 0.83 | GSK3A (0.48) | GSK3BGSK3AADORA1 | |
| SCHEMBL3525610 | 0.82 | GSK3B (0.55) | GSK3BGSK3AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |