Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.46 |
| ▸ | GSK3A | P49840 | 8/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550039 | 0.91 | GSK3A (0.46) | GSK3BGSK3AADORA1TP53MAPT | |
| SCHEMBL5549261 | 0.88 | KMT2A (0.48) | TP53MAPTLMNA | |
| SCHEMBL3529920 | 0.88 | GSK3A (0.61) | GSK3BGSK3ALMNAFABP4 | |
| SCHEMBL5543524 | 0.88 | ADORA1 (0.43) | GSK3BGSK3AADORA1 | |
| SCHEMBL5549402 | 0.88 | ADORA1 (0.43) | GSK3BGSK3AADORA1MAPT | |
| SCHEMBL5543493 | 0.88 | GSK3B (0.50) | GSK3BGSK3AADORA1TP53MAPT | |
| SCHEMBL3528033 | 0.86 | GSK3B (0.56) | GSK3BGSK3AADORA1 | |
| SCHEMBL3527695 | 0.86 | GSK3B (0.42) | GSK3BGSK3AADORA1MAPTLMNA | |
| SCHEMBL5548613 | 0.84 | L3MBTL1 (0.41) | GSK3BGSK3AMAPT | |
| SCHEMBL3526786 | 0.83 | GSK3B (0.56) | GSK3BGSK3AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |