Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13674536 | 1.00 | HRH3 (0.39) | HRH3ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL4505542 | 0.92 | MAP3K14 (0.39) | ACVRL1ACVR1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL13674538 | 0.92 | MAP3K14 (0.39) | ACVRL1ACVR1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL4518204 | 0.92 | ACVRL1 (0.38) | HRH3ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL13674537 | 0.92 | ACVRL1 (0.38) | HRH3ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL13674540 | 0.89 | HSD11B1 (0.37) | ACVRL1ACVR1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL4508940 | 0.89 | HSD11B1 (0.37) | ACVRL1ACVR1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL13674530 | 0.89 | AVPR1A (0.43) | HRH3ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL4515579 | 0.89 | AVPR1A (0.43) | HRH3ACVRL1ACVR1BMPR1BBMPR1A | |
| SCHEMBL13675512 | 0.86 | HRH3 (0.39) | HRH3PGRMCHR1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1864971-A1 | PROPHYLACTIC/THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2007-12-12 | — | — | EP | disclosed |