Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546597 | 0.81 | CCR3 (0.39) | GRM5L3MBTL1ALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL5547993 | 0.80 | GRM5 (0.41) | GRM5L3MBTL1ALDH1A1 | |
| SCHEMBL5548541 | 0.72 | SIRT2 (0.37) | GRM5L3MBTL1RAB9ANPC1LMNA | |
| SCHEMBL5546577 | 0.66 | CHRM5 (0.38) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5546867 | 0.66 | MEN1 (0.36) | CHRNB2CHRNA7CHRNA4KMT2A | |
| SCHEMBL3537033 | 0.62 | KDR (0.50) | GRM5L3MBTL1GAALMNA | |
| SCHEMBL28975696 | 0.58 | L3MBTL1 (0.88) | GRM5L3MBTL1RAB9ANPC1PKM | |
| SCHEMBL4877455 | 0.57 | LMNA (0.57) | NPC1GAAALDH1A1SMN1; SMN2MAPK8 | |
| SCHEMBL27878926 | 0.56 | PDE4A (0.40) | L3MBTL1RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL6682650 | 0.56 | CHRNA7 (0.62) | GRM5L3MBTL1RAB9ANPC1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |