Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 6/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5543068 | 0.90 | SMN1; SMN2 (0.41) | PTGS2ADORA1MEN1LMNAPOLB | |
| SCHEMBL5543318 | 0.82 | MEN1 (0.40) | ADORA1GSK3BGSK3AMEN1KMT2A | |
| SCHEMBL3528033 | 0.82 | GSK3B (0.56) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545517 | 0.80 | GSK3B (0.54) | ADORA1GSK3BGSK3ALMNARAB9A | |
| SCHEMBL5549402 | 0.79 | ADORA1 (0.43) | GPR84ADORA1GSK3BGSK3AMEN1 | |
| SCHEMBL5543493 | 0.79 | GSK3B (0.50) | GPR84ADORA1GSK3BGSK3AMAPT | |
| SCHEMBL5543524 | 0.79 | ADORA1 (0.43) | GPR84ADORA1GSK3BGSK3A | |
| SCHEMBL5545556 | 0.79 | GSK3A (0.48) | ADORA1GSK3BGSK3A | |
| SCHEMBL3521775 | 0.79 | GSK3B (0.36) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545590 | 0.79 | GSK3B (0.35) | ADORA1GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |