Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 13/20 | 0.36 |
| ▸ | GSK3A | P49840 | 12/20 | 0.35 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549007 | 0.91 | KMT2A (0.51) | MEN1PKMKMT2AHSD17B10 | |
| SCHEMBL5545549 | 0.82 | CASP1 (0.43) | MEN1KMT2AADORA1GSK3BGSK3A | |
| SCHEMBL3528033 | 0.81 | GSK3B (0.56) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545517 | 0.80 | GSK3B (0.54) | ADORA1GSK3BGSK3A | |
| SCHEMBL5545556 | 0.80 | GSK3A (0.48) | ADORA1GSK3BGSK3A | |
| SCHEMBL5543524 | 0.80 | ADORA1 (0.43) | ADORA1GSK3BGSK3A | |
| SCHEMBL5543493 | 0.80 | GSK3B (0.50) | ADORA1GSK3BGSK3A | |
| SCHEMBL3529268 | 0.80 | ADORA1 (0.37) | HSD17B10ADORA1GSK3BGSK3A | |
| SCHEMBL3521775 | 0.80 | GSK3B (0.36) | ADORA1GSK3BGSK3A | |
| SCHEMBL3525610 | 0.80 | GSK3B (0.55) | HSD17B10ADORA1IGF1RFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |