Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3523472 | 0.75 | NPC1 (0.38) | ENPP2TP53MAPT | |
| SCHEMBL4478551 | 0.74 | CNR1 (0.39) | ENPP2SMPD1TP53THRB | |
| SCHEMBL4623854 | 0.69 | MEN1 (0.46) | ENPP2TLR8MEN1KMT2ASMPD1 | |
| SCHEMBL4623900 | 0.69 | TLR8 (0.47) | ENPP2TLR8MEN1KMT2ASMPD1 | |
| SCHEMBL17401378 | 0.68 | ENPP2 (0.93) | ENPP2 | |
| SCHEMBL14180976 | 0.68 | CNR1 (0.52) | MEN1KMT2ASMPD1TP53MAPT | |
| SCHEMBL17401560 | 0.68 | ENPP2 (0.64) | ENPP2TLR8 | |
| SCHEMBL17391730 | 0.67 | ENPP2 (0.79) | ENPP2 | |
| SCHEMBL17401555 | 0.66 | ENPP2 (0.67) | ENPP2 | |
| SCHEMBL17391719 | 0.66 | ENPP2 (0.98) | ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |